Hydroxypropyl Methyl Cellulose (HPMC) is a semi-synthetic, viscoelastic polymer which is a cellulose ether. Hydroxypropylmethylcellulose (HPMC) is soluble in some organic solvents, as well as in solvent mixtures of water-organic solvents. It does not gel when heated.HPMC is a non-toxic raw material derived from cotton and wood.
Hydroxypropylmethylcellulose (HPMC) is hygroscopic after drying, but stable. Its solutions are stable at pH 4-8 (1% solution 25°C). The viscosity of the solution decreases with increasing temperature. Heating-cooling reversibly transforms HPMC from a solution state to a gel. Depending on the grade and concentration, the gel temperature ranges from 50 to 90°C. HPMC aqueous solutions are anti-enzymatic and maintain good viscosity stability during long-term storage. However, its aqueous solution is susceptible to microbial attack and preservatives should be added during storage.
(Hydroxypropyl)methyl cellulose (HPMC) has been used:
As a viscosity modifier in the preparation of printable inks
Tackifier in the preparation of hydroxyapatite (HAP) suspensions
Preparation of HPMC gels and composite gels
Thickeners for aqueous and non-aqueous systems, transparent films with grease resistance, adhesives, lubricants, space stabilizers and water retention agents.
(Hydroxypropyl)methyl cellulose (HPMC) is used as a suspension aid, surfactant, lubricant, protective colloid and emulsifier. In addition, solutions of these polymers exhibit thermogel properties. They are commonly used as binders, thickeners, film-formers and water-holding agents.HPMC also has surface-active properties.
Soluble in water, reversible gelation on heating, non-ionic, does not complex with ionic substances, surface active and enzyme resistant. The solution is pseudoplastic.
Other Precautions
Store in a cool, well-ventilated place away from extreme heat and strong oxidizing agents.
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